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To stay healthy, don't just watch what you eat – watch when you eat it.

New research is driving that point home by looking at the impact of changes in meal timing from day-to-day and from weekday-to-weekend. Those changes were associated with several important heart health risk factors, including changes in waist circumference, body fat, blood pressure and blood sugar, said lead researcher Nour Makarem, an associate research scientist at Columbia University Irving Medical Center in New York.

Her own had shown that eating more in the evening can increase a person's risk for heart disease. "But here, we show that it's not just about eating timing – it's also about the day-to-day regularity and the weekend-weekday regularity in our food intake," Makarem said.

The , considered preliminary until published in a peer-reviewed journal, was presented recently at the ľ¹ÏÖ±²¥'s virtual Scientific Sessions conference.

Makarem and her co-authors studied a group of 116 racially and ethnically diverse women, ages 20 to 64, who were part of the AHA's . For a week, they used an electronic food diary to track what and when they ate. A year later, 99 of the women returned and repeated the process.

The idea that people shift their sleep patterns on the weekend has been dubbed "social jet lag." Makarem's team looked at day-to-day shifts in eating timing, duration of the eating period, evening eating and "eating jet lag" – differences in when they ate on weekdays versus weekends. The study looked at the timing of the women's first and last eating occasion of the day; how long they went without food overnight; and what percentage of daily calories they consumed after 5 p.m. and 8 p.m.

When researchers looked at day-to-day variability in eating patterns, they saw that for every 10% increase in inconsistency in calories consumed after 5 p.m., the women had an increase of nearly three points in their systolic blood pressure (the top number in a reading) and more than two points in their diastolic blood pressure (the bottom number) over the study's one-year follow-up period. They also saw a significant change in HbA1c, an important blood sugar measurement used to diagnose diabetes.

Similarly, findings showed that an increase in day-to-day variability in calories eaten after 8 p.m. was related to more than a half-inch gain in waist size and a half-point increase in body mass index, a marker of body fat and body weight status.

When focusing on differences between weekdays and weekends, increased variability in timing and extent of evening eating and in duration of the eating period was linked to increases in systolic and diastolic blood pressure and in BMI a year later.

But you don't have to give up your late brunch on Saturday just yet.

"It's not necessarily that on the weekend our eating timing is worse," Makarem said. "It's just that on weekdays, we're following a social clock, whereas on the weekend, we're following our natural biologic clock." In other words, what's natural for our bodies is constrained by the demands and schedules of modern life.

Makarem explained that the body's circadian rhythms – the innate or natural rhythms in our physiology, behavior and metabolism that evolved as an adaption to the 24-hour cycle of light and dark – ensure our body is synchronized with the environment and performs functions at optimal times.

These circadian rhythms are controlled by a "master clock" in the brain, she said. But individual organs, including those involved in metabolic processes that affect the risk of heart disease, have their own clocks. "And these clocks are regulated by food intake."

Dr. Deepak L. Bhatt, a professor of medicine at Harvard Medical School who was not involved in the research, said it can be hard to single out the precise links between meal timing, sleeping and heart health.

"All these relationships are difficult because nothing travels in isolation," said Bhatt, executive director of Interventional Cardiovascular Programs at Brigham and Women's Hospital Heart and Vascular Center in Boston. "All these things travel in packs. That is – somebody who's staying up late at night and eating late at night – they're also perhaps not getting a good night's sleep. That can also predispose them to weight gain."

When people eat during the day, they can burn off some of the calories through normal activity, he said. But someone staying up late, whether pulling an all-nighter or watching TV, still gets hungry. And that extra snack or meal "really goes right to the gut."

The study emphasizes why it's important to watch the timing of your eating no matter what, Bhatt said. "Even if one feels they can't control their hours of sleep cycle, or their weekday-weekend mix of what hours they're awake and asleep, they can control what they put in their mouth and when."

Makarem said the COVID-19 pandemic could be further contributing to the disruption of eating and sleeping cycles. Given her study's relatively small size and its focus on women, more research is needed before widespread recommendations could be made, she said.

Bhatt emphasized that common sense should prevail. "To the extent modern life allows, trying to have regular eating patterns and sleeping patterns, as most of our mothers probably told us, is just good advice."

Find more news from Scientific Sessions.

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